Uncovering hidden sources of SARS-CoV-2 viral evolution: A call to actionEditorial Published on 2022-12-012023-07-10 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), [키워드] bamlanivimab immunosuppression. SARS-CoV-2 evolution [DOI] 10.1111/tid.13910 PMC 바로가기 [Article Type] Editorial
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitorsArticle Published on 2022-11-012022-11-15 Journal: Nature chemical biology [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding component conserved coronavirus defined Diseases epitope Epitopes highlighting inhibitor inhibitors inhibitory linker monoclonal neutralize Neutralizing activity non-neutralizing antibody omicron pandemic receptor SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-CoV-2 variant target the SARS-CoV-2 Treatment viral spike protein VOCs [DOI] 10.1038/s41589-022-01140-1 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccinesArticle Published on 2022-10-102022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Algorithm amino acid substitution change Clinical efficacy clinical sample correlation D614G decrease determine dynamic Efficacy Endemic epitope Epitopes Evolution Evolution of SARS-CoV-2 immune immunogenic indicated lineages mAb monitoring monoclonal antibodies Mutation mutations Pearson positive positive correlation predicted Predictive Prevalence prevalent resulting SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome spike mutation Spike protein Spread Substitution Vaccine Vaccine design variant virus [DOI] 10.1038/s42003-022-04030-3 PMC 바로가기
Population genetic models for the spatial spread of adaptive variants: A review in light of SARS-CoV-2 evolutionArticle Published on 2022-09-222022-11-16 Journal: PLoS Genetics [Category] SARS, 변종, [키워드] adaptive Analysis Characteristics consequence coronavirus 2 Course COVID-19 pandemic dispersal Evolution future work Genetic genetic model genetics identify Lineage mathematical natural selection pandemic Pandemics Population populations respiratory SARS-CoV-2 SARS-CoV-2 evolution Spread Travel variant variants of concern [DOI] 10.1371/journal.pgen.1010391 PMC 바로가기
SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patientArticle Published on 2022-09-012022-11-16 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid approach changes in chronic infection Combination deep sequencing deletions demonstrated Evolution favor Genetic Host immune evasion Immunocompromised immunocompromised individual Immunocompromised patient Infection intra-host evolution investigated Mutation Nasopharyngeal swab new SARS-CoV-2 Patient Prolonged Prolonged infection Protein SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage sequencing. suggested the SARS-CoV-2 the Spike variant variants with HIV [DOI] 10.1016/j.ijid.2022.06.023 PMC 바로가기
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America북미에서 재조합 SARS-CoV-2 계통의 출현 및 광범위한 유통Article Published on 2022-08-102022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysis circulation Cluster coronavirus Deletion distribution Effect emergence Evolution Genome geographical region Lineage lineages molecular Molecular epidemiology non-structural protein North America NSP6 ORF3a Phylogenetic Phylogenetic analysis phylogenetics Protein question raise Recombination recombination event recombination. SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage shown spatiotemporal spike supported USA virus virus widespread [DOI] 10.1016/j.chom.2022.06.010 PMC 바로가기 [Article Type] Article
Interferon resistance of emerging SARS-CoV-2 variants새로운 SARS-CoV-2 변이체의 인터페론 내성Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] (Alpha) (Beta) Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Course COVID-19 COVID-19 pandemic Critical driving ENhance exhibited FIVE highlight implication include infections Innate immunity interferon interferon response interferons isolates lethality limit lineages Mutation neutralizing antibody outbreak P.1 Pathogenesis potency responses SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants spike spike mutations subtype the interferon Transmissibility Treatment Vaccine variant variants variants of concern variants of concern. Viral viral gene viral genes viral lineage virus infectivity while [DOI] 10.1073/pnas.2203760119 PMC 바로가기 [Article Type] Article